Over the past 15 years, rapid progress has been made in developmental therapeutics,
especially regarding the use of matched targeted therapies against specific oncogenic …

Molecular tumor boards (MTB) are interdisciplinary conferences involving various experts
discussing patients with advanced tumors, to derive individualized treatment suggestions …

Genomics studies routinely confront researchers with long lists of tumor alterations detected
in patients. Such lists are difficult to interpret since only a minority of the alterations are …

Massively parallel sequencing helps create new knowledge on genes, variants and their
association with disease phenotype. This important technological advancement …

Dealing with sequence coordinates in different formats and reference genomes is
challenging in genetic research. This complexity arises from the need to convert and …

The employment of drug combinations in cancer therapy plays an important role, enhancing
efficacy and reducing toxicity. However, the ability to identify and validate effective drug …

One of the major challenges in precision medicine is the identification of pathogenic,
actionable variants and the selection of personalized treatments. We present Onkopus, a …

NGS is increasingly used in precision medicine, but an automated sequencing pipeline that
can detect different types of variants (single nucleotide-SNV, copy number-CNV, structural …

Background: Cancer variability among patients underscores the need for personalized
therapy based on genomic understanding. BRCAness, characterized by vulnerabilities …

Mature T-cell lymphomas and leukemias (mTCL) comprise a clinically and genetically
heterogeneous group of lymphoid malignancies. Most subtypes of peripheral T-cell …