What drives osteoarthritis?—synovial versus subchondral bone pathology

T Hügle, J Geurts - Rheumatology, 2017 - academic.oup.com
Subchondral bone and the synovium play an important role in the initiation and progression
of OA. MRI often permits an early detection of synovial hypertrophy and bone marrow …

Wolff's law in action: a mechanism for early knee osteoarthritis

AJ Teichtahl, AE Wluka, P Wijethilake, Y Wang… - Arthritis research & …, 2015 - Springer
There is growing interest in the role of bone in knee osteoarthritis. Bone is a dynamic organ,
tightly regulated by a multitude of homeostatic controls, including genetic and environmental …

Radiographic Biomarkers for Knee Osteoarthritis: A Narrative Review

A Almhdie-Imjabbar, H Toumi, E Lespessailles - Life, 2023 - mdpi.com
Conventional radiography remains the most widely available imaging modality in clinical
practice in knee osteoarthritis. Recent research has been carried out to develop novel …

Elevated marrow inflammatory cells and osteoclasts in subchondral osteosclerosis in human knee osteoarthritis

J Geurts, A Patel, MT Hirschmann… - Journal of …, 2016 - Wiley Online Library
Subchondral osteosclerosis, characterized by an increase of hypomineralized bone
material, is a pathological hallmark of osteoarthritis. The cellular components in the …

Trabecular bone texture analysis of conventional radiographs in the assessment of knee osteoarthritis: review and viewpoint

A Almhdie-Imjabbar, P Podsiadlo, R Ljuhar… - Arthritis Research & …, 2021 - Springer
Background Trabecular bone texture analysis (TBTA) has been identified as an imaging
biomarker that provides information on trabecular bone changes due to knee osteoarthritis …

MRI texture analysis of subchondral bone at the tibial plateau

JW MacKay, PJ Murray, B Kasmai, G Johnson… - European …, 2016 - Springer
Objectives To determine the feasibility of MRI texture analysis as a method of quantifying
subchondral bone architecture in knee osteoarthritis (OA). Methods Asymptomatic subjects …

Biomarkers of joint metabolism and bone mineral density are associated with early knee osteoarthritis in premenopausal females

N Hu, J Zhang, J Wang, P Wang, J Wang, Y Qiang… - Clinical …, 2022 - Springer
Introduction Biomarkers of bone and cartilage metabolism were proposed as early diagnosis
indicators for knee osteoarthritis (OA), however, which were influenced by disease stage …

Short-term variations in trabecular bone texture parameters associated to radio-clinical biomarkers improve the prediction of radiographic knee osteoarthritis …

A Almhdie-Imjabbar, H Toumi, E Lespessailles - Scientific Reports, 2023 - nature.com
The present study aims to examine whether the short-term variations in trabecular bone
texture (TBT) parameters, combined with a targeted set of clinical and radiographic data …

Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

AJ Teichtahl, Y Wang, AE Wluka, BJ Strauss… - Arthritis research & …, 2017 - Springer
Background Osteoarthritis has a high prevalence in people with high bone mineral density
(BMD). Nevertheless, whether high systemic BMD predates early structural features of knee …

Medial versus lateral condyle bone mineral density ratios in a cross‐sectional study: A potential marker for medial knee osteoarthritis severity

Y Akamatsu, N Mitsugi, N Taki… - Arthritis Care & …, 2012 - Wiley Online Library
Objective To assess the association of bone mineral density (BMD) of the femoral and tibial
condyles with knee pain and disease severity in women with symptomatic medial knee …