Transgenerational epigenetic inheritance: myths and mechanisms

E Heard, RA Martienssen - Cell, 2014 - cell.com
Since the human genome was sequenced, the term" epigenetics" is increasingly being
associated with the hope that we are more than just the sum of our genes. Might what we …

Exploiting induced and natural epigenetic variation for crop improvement

NM Springer, RJ Schmitz - Nature reviews genetics, 2017 - nature.com
Plant breeding has traditionally relied on combining the genetic diversity present within a
species to develop combinations of alleles that provide desired traits. Epigenetic diversity …

[HTML][HTML] Epigenomic diversity in a global collection of Arabidopsis thaliana accessions

T Kawakatsu, SC Huang, F Jupe, E Sasaki, RJ Schmitz… - Cell, 2016 - cell.com
The epigenome orchestrates genome accessibility, functionality, and three-dimensional
structure. Because epigenetic variation can impact transcription and thus phenotypes, it may …

Widespread natural variation of DNA methylation within angiosperms

CE Niederhuth, AJ Bewick, L Ji, MS Alabady, KD Kim… - Genome biology, 2016 - Springer
Background DNA methylation is an important feature of plant epigenomes, involved in the
formation of heterochromatin and affecting gene expression. Extensive variation of DNA …

DNA methylation in Arabidopsis has a genetic basis and shows evidence of local adaptation

MJ Dubin, P Zhang, D Meng, MS Remigereau… - elife, 2015 - elifesciences.org
Epigenome modulation potentially provides a mechanism for organisms to adapt, within and
between generations. However, neither the extent to which this occurs, nor the mechanisms …

DNA methylation landscapes: provocative insights from epigenomics

MM Suzuki, A Bird - Nature reviews genetics, 2008 - nature.com
The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine.
To understand the biological significance of this epigenetic mark it is essential to know …

Spontaneous epigenetic variation in the Arabidopsis thaliana methylome

C Becker, J Hagmann, J Müller, D Koenig, O Stegle… - Nature, 2011 - nature.com
Heritable epigenetic polymorphisms, such as differential cytosine methylation, can underlie
phenotypic variation,. Moreover, wild strains of the plant Arabidopsis thaliana differ in many …

Transgenerational epigenetic instability is a source of novel methylation variants

RJ Schmitz, MD Schultz, MG Lewsey, RC O'Malley… - Science, 2011 - science.org
Epigenetic information, which may affect an organism's phenotype, can be stored and stably
inherited in the form of cytosine DNA methylation. Changes in DNA methylation can produce …

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

SJ Cokus, S Feng, X Zhang, Z Chen, B Merriman… - Nature, 2008 - nature.com
Cytosine DNA methylation is important in regulating gene expression and in silencing
transposons and other repetitive sequences,. Recent genomic studies in Arabidopsis …

Integrative epigenomic mapping defines four main chromatin states in Arabidopsis

F Roudier, I Ahmed, C Bérard, A Sarazin… - The EMBO …, 2011 - embopress.org
Post‐translational modification of histones and DNA methylation are important components
of chromatin‐level control of genome activity in eukaryotes. However, principles governing …