How distal cis-regulatory elements (eg, enhancers) communicate with promoters remains an
unresolved question of fundamental importance. Although transcription factors and cofactors …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Modern drug design aims to discover novel lead compounds with attractable chemical
profiles to enable further exploration of the intersection of chemical space and biological …

Background Marine seaweeds are considered as a rich source of health-promoting
compounds by the food and pharmaceutical industry. Hypnea musciformis is a marine red …

Effective organization of proteins into functional modules (networks, pathways) requires
systems-level coordination between transcription, translation and degradation. Whereas the …

Prostate cancer is one of the most common malignant diseases in men, and it contributes
significantly to the increased mortality rate in men worldwide. This study aimed to review the …

Abstract p53 mutations with single amino acid changes in cancer often lead to dominant
oncogenic changes. Here, we have developed a mouse model of gain-of-function (GOF) …

Simple Summary Cisplatin resistance is a common issue that affects patients with a variety
of cancers who are treated with this drug. In this research, we present a novel epigenetic …

Recent studies have suggested that microRNA let-7i is a tumor suppressor in human
cancers, including esophageal cancer, but its underlying mechanism is not yet fully …

Simple Summary Post-translational modifications (PTMs) strongly influence the stability and
function of proteins. These modifications have been reported to affect wild-type (wt) p53 as …