Exosomes, a new star for targeted delivery

H Chen, L Wang, X Zeng, H Schwarz… - Frontiers in cell and …, 2021 - frontiersin.org
Exosomes are cell-secreted nanoparticles (generally with a size of 30–150 nm) bearing
numerous biological molecules including nucleic acids, proteins and lipids, which are …

Technological advances towards extracellular vesicles mass production

A Grangier, J Branchu, J Volatron, M Piffoux… - Advanced Drug Delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are becoming essential actors in bio-therapeutics, as much for
their regenerative or immunomodulatory properties as for their potential as cargo delivery …

[HTML][HTML] Exosomes and their bioengineering strategies in the cutaneous wound healing and related complications: current knowledge and future perspectives

G Yang, S Waheed, C Wang, M Shekh… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Exosomes, as therapeutically relevant cell-secreted extracellular vesicles, have attracted
enormous interest because they participate in intercellular communication and facilitate …

Separation, characterization, and standardization of extracellular vesicles for drug delivery applications

D Buschmann, V Mussack, JB Byrd - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicles (EVs) are membranous nanovesicles secreted from living cells,
shuttling macromolecules in intercellular communication and potentially possessing intrinsic …

Current challenges in biotherapeutic particles manufacturing

MG Moleirinho, RJS Silva, PM Alves… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: The development of novel complex biotherapeutics led to new challenges in
biopharmaceutical industry. The potential of these particles has been demonstrated by the …

Extracellular vesicle-based therapeutics: preclinical and clinical investigations

NL Klyachko, CJ Arzt, SM Li, OA Gololobova… - Pharmaceutics, 2020 - mdpi.com
Drug nanoformulations hold remarkable promise for the efficient delivery of therapeutics to a
disease site. Unfortunately, artificial nanocarriers, mostly liposomes and polymeric …

Challenges and strategies: scalable and efficient production of mesenchymal stem cells-derived exosomes for cell-free therapy

W Pan, H Chen, A Wang, F Wang, X Zhang - Life sciences, 2023 - Elsevier
Exosomes are small membrane vesicles secreted by most cell types, and widely exist in cell
supernatants and various body fluids. They can transmit numerous bioactive elements, such …

Advances in lentivirus purification

AS Moreira, DG Cavaco, TQ Faria… - Biotechnology …, 2021 - Wiley Online Library
Lentiviral vectors (LVs) have been increasingly used as a tool for gene and cell therapies
since they can stably integrate the genome in dividing and nondividing cells. LV production …

Forging new therapeutic targets: efforts of tumor derived exosomes to prepare the pre-metastatic niche for cancer cell dissemination and dormancy

R Bhatia, J Chang, JL Munoz, ND Walker - Biomedicines, 2023 - mdpi.com
Tumor-derived exosomes play a multifaceted role in preparing the pre-metastatic niche,
promoting cancer dissemination, and regulating cancer cell dormancy. A brief review of …

Techniques for increasing the yield of stem cell-derived exosomes: what factors may be involved?

ZY Feng, QY Zhang, J Tan, HQ Xie - Science China Life sciences, 2022 - Springer
Exosomes are nano-scale extracellular vesicles secreted by cells and constitute an
important part in the cell-cell communication. The main contents of the exosomes include …