Molecular bases of VEGFR-2-mediated physiological function and pathological role

X Wang, AM Bove, G Simone, B Ma - Frontiers in Cell and …, 2020 - frontiersin.org
The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial
roles in vasculogenesis and angiogenesis. Angiogenesis is an important mechanism in …

[HTML][HTML] Vascular endothelial growth factor receptor (VEGFR-2)/KDR inhibitors: medicinal chemistry perspective

SJ Modi, VM Kulkarni - Medicine in Drug Discovery, 2019 - Elsevier
New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …

Signal transduction by vascular endothelial growth factor receptors

S Koch, L Claesson-Welsh - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Vascular endothelial growth factors (VEGFs) are master regulators of vascular development
and of blood and lymphatic vessel function during health and disease in the adult. It is …

Signal transduction by vascular endothelial growth factor receptors

S Koch, S Tugues, X Li, L Gualandi… - Biochemical …, 2011 - portlandpress.com
VEGFs (vascular endothelial growth factors) control vascular development during
embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There …

VEGF receptor signalling? In control of vascular function

AK Olsson, A Dimberg, J Kreuger… - … reviews Molecular cell …, 2006 - nature.com
Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system.
VEGFR1 is required for the recruitment of haematopoietic precursors and migration of …

Endothelial cell migration during angiogenesis

L Lamalice, F Le Boeuf, J Huot - Circulation research, 2007 - Am Heart Assoc
Endothelial cell migration is essential to angiogenesis. This motile process is directionally
regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves …

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition

K Holmes, OL Roberts, AM Thomas, MJ Cross - Cellular signalling, 2007 - Elsevier
Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis
and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the …

The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions

H Takahashi, M Shibuya - Clinical science, 2005 - portlandpress.com
The VEGF (vascular endothelial growth factor) family and its receptors are essential
regulators of angiogenesis and vascular permeability. Currently, the VEGF family consists of …

Vascular endothelial growth factor in eye disease

JS Penn, A Madan, RB Caldwell, M Bartoli… - Progress in retinal and …, 2008 - Elsevier
Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision
loss in developed countries. In the US, for example, retinopathy of prematurity, diabetic …

VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin

J Gavard, JS Gutkind - Nature cell biology, 2006 - nature.com
How vascular endothelial growth factor (VEGF) induces vascular permeability, its first
described function, remains poorly understood. Here, we provide evidence of a novel …