RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …

Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize
post-transcriptional control mechanisms to re-program gene expression in ways that …

Summary tRNA is a central component of protein synthesis and the cell signaling network.
One salient feature of tRNA is its heavily modified status, which can critically impact its …

Translational control plays an essential role in the regulation of gene expression. It is
especially important in defining the proteome, maintaining homeostasis, and controlling cell …

During the past decade, there has been growing interest in the role of translational
regulation of gene expression in many organisms. Polysome profiling has been developed …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function
underlie a broad spectrum of human pathologies. We focus here on two recent studies that …

The regulation of mRNA translation is a major checkpoint in the flux of information from the
transcriptome to the proteome. Critical for translational control are the trans-acting factors …

Drosophila eggs are highly polarised cells that use RNA–protein complexes to regulate
storage and translational control of maternal RNAs. Ribonucleoprotein granules are a class …

The high‐throughput sequencing of cellular RNAs has underscored a broad effect of isoform
diversification through alternative splicing on the transcriptome. Moreover, the differential …