Despite advances in the field of male reproductive health, idiopathic male infertility, in which
a man has altered semen characteristics without an identifiable cause and there is no …

Spermatozoon is a motile cell with a special ability to travel through the woman's
reproductive tract and fertilize an oocyte. To reach and penetrate the oocyte, spermatozoa …

Mitochondria have multiple functions, including synthesis of adenine triphosphate,
production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis …

Redox regulation and oxidative stress have become areas of major interest in spermatology.
Alteration of redox homeostasis is recognized as a significant cause of male factor infertility …

Proteomics and metabolomics are emerging as promising tools to investigate the molecular
mechanisms associated with male infertility. Proteins and metabolites play a pivotal role in …

Both oxidative stress (OS) and reductive stress (RS) are the two extreme facets of redox
imbalance that can have deleterious effects on sperm function. However, there is a lack of …

Human sperm proteomics research has gained increasing attention lately, which provides
complete information about the functional state of the spermatozoa. Changes in the sperm …

Male infertility is a widespread health problem affecting approximately 6%–8% of the male
population, and hypoxia may be a causative factor. In mammals, two types of hypoxia are …

Background Varicocoele is a common risk factor associated with reduced male fertility
potential. The current understanding of varicocoele pathophysiology does not completely …

Male infertility is a rising problem and the etiology at the molecular level is unclear. Use of
omics has provided an insight into the underlying cellular changes in the spermatozoa of …