The central nervous system (CNS) tissues, including the brain, the eye, and the spinal cord,
are immune‐privileged, secluded from the circulation by a complex of barriers, and …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
known for the manifestation of demyelinated lesions throughout the CNS, leading to …

Abstract Objective: Microvesicles (MVs) have been indicated as important mediators of
intercellular communication and are emerging as new biomarkers of tissue damage. Our …

The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the
subventricular zone (SVZ). Whether or not these cells exert physiological functions is still …

Microglia activation is a commonly pathological hallmark of neurodegenerative diseases,
such as amyotrophic lateral sclerosis (ALS), a devastating disorder characterized by a …

Neural stem cells (NSCs) persist in defined brain niches, including the subventricular zone
(SVZ), throughout adulthood and generate new neurons destined to support specific …

Synaptic dysfunction triggers neuronal damage in experimental autoimmune
encephalomyelitis (EAE), a model of multiple sclerosis (MS). While excessive glutamate …

B cells play a central role in multiple sclerosis (MS) pathology. B and plasma cells may
contribute to disease activity through multiple mechanisms: antigen presentation, cytokine …

Multiple sclerosis (MS) as a chronic inflammatory disorder of the central nervous system
(CNS) is thought to be caused by the abnormal induction of immune responses …

By serving as the sole output of the cerebellar cortex, integrating a myriad of afferent stimuli,
Purkinje cells (PCs) constitute the principal neuron in cerebellar circuits. Several …