The circadian clock regulates immune responses to microbes and affects pathogen
replication, but the underlying molecular mechanisms are not well understood. Here we …

Hepatitis C virus (HCV) genotype (gt) 3 is highly prevalent globally, with non‐gt3a subtypes
common in Southeast Asia. Resistance‐associated substitutions (RASs) have been shown …

Background: As long as COVID-19 endures, viral surface proteins will keep changing and
new viral strains will emerge, rendering prior vaccines and treatments decreasingly effective …

Despite the widespread use of the COVID-19 vaccines, the search for effective antiviral
drugs for the treatment of patients infected with SARS-CoV-2 is still relevant. Genetic …

Abstract Background & Aims Oestrogen and oestrogen‐mediated signalling protect from
hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain …

Simple Summary Chronic hepatitis C virus (HCV) infection is a common cause of liver
cancer in the developed world. Although anti-viral treatment can cure HCV infection, the risk …

Hepatitis C virus (HCV) and classical swine fever virus (CSFV) are important pathogens for
which new therapeutic approaches are in high demand. Herein, we report the synthesis of …

Hepatitis C virus (HCV) infects millions of people worldwide and is a leading cause of liver
disease. Despite recent advances in antiviral therapies, viral resistance can limit drug …

A series of 1-[(bromophenoxy) alkyl] uracil–coumarin conjugates has been obtained through
the preparation of starting 1-[(bromophenoxy) alkyl] uracil derivatives, followed by their …

А series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen
atom N3 of the pyrimidine ring by a short methylene bridge was synthesized to search for …