Protein tyrosine phosphatase 1B inhibitors for diabetes
TO Johnson, J Ermolieff, MR Jirousek - Nature Reviews Drug Discovery, 2002 - nature.com
Increased incidence of type 2 diabetes mellitus and obesity has elevated the medical need
for new agents to treat these disease states. Resistance to the hormones insulin and leptin …
for new agents to treat these disease states. Resistance to the hormones insulin and leptin …
Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development
AJ Barr - Future medicinal chemistry, 2010 - Taylor & Francis
Several 'classical'protein tyrosine phosphatases are attractive therapeutic targets, including
PTP1B for obesity and Type II diabetes; SHP2 for cancer and Lyp for rheumatoid arthritis …
PTP1B for obesity and Type II diabetes; SHP2 for cancer and Lyp for rheumatoid arthritis …
Promotion of green financing: Role of renewable energy and energy transition in China
G Sun, G Li, A Dilanchiev, A Kazimova - Renewable Energy, 2023 - Elsevier
This study examined the influence of green financing, renewable energy, and energy
transition. Although the importance of natural resources has been discussed in the current …
transition. Although the importance of natural resources has been discussed in the current …
Do natural resources play a role in economic development? Role of institutional quality, trade openness, and FDI
J Wang, J Yang, L Yang - Resources Policy, 2023 - Elsevier
The decline in environmental quality is influenced by natural resource use, which, in turn,
affects economic growth. The Sustainable Development Goal (SDG) has helped bring …
affects economic growth. The Sustainable Development Goal (SDG) has helped bring …
Does industrial structure changes matter in renewable energy development? Mediating role of green finance development
S Zhao, X He, KU Faxritdinovna - Renewable Energy, 2023 - Elsevier
Green financing development mediated the interaction between industrial structure changes
and renewable energy growth in China from 2000 to 2021. The research examines whether …
and renewable energy growth in China from 2000 to 2021. The research examines whether …
Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus
S Koren, IG Fantus - Best practice & research Clinical endocrinology & …, 2007 - Elsevier
The global epidemic of obesity and type-2 diabetes mellitus (T2DM) has highlighted the
need for new therapeutic approaches. The association of insulin resistance with these …
need for new therapeutic approaches. The association of insulin resistance with these …
Protein tyrosine phosphatase 1B (PTP1B) and obesity
H Cho - Vitamins & Hormones, 2013 - Elsevier
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the leptin and insulin
signaling pathways. The important roles of PTP1B related to obesity and diabetes were …
signaling pathways. The important roles of PTP1B related to obesity and diabetes were …
Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy
BG Szczepankiewicz, G Liu, PJ Hajduk… - Journal of the …, 2003 - ACS Publications
Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that downregulates the insulin
receptor. Inhibition of PTP1B is expected to improve insulin action, and the design of small …
receptor. Inhibition of PTP1B is expected to improve insulin action, and the design of small …
PTP1B and TCPTP–nonredundant phosphatases in insulin signaling and glucose homeostasis
T Tiganis - The FEBS journal, 2013 - Wiley Online Library
Insulin resistance is a key pathological feature of type 2 diabetes and is characterized by
defects in signaling by the insulin receptor (IR) protein tyrosine kinase. The inhibition of …
defects in signaling by the insulin receptor (IR) protein tyrosine kinase. The inhibition of …
Perspectives for vanadium in health issues
D Rehder - Future medicinal chemistry, 2016 - Taylor & Francis
Vanadium is omnipresent in trace amounts in the environment, in food and also in the
human body, where it might serve as a regulator for phosphate-dependent proteins …
human body, where it might serve as a regulator for phosphate-dependent proteins …