Objective This study aimed to determine the dose–response relationship between
prolonged sitting and vascular function in healthy individuals and those with metabolic …

The pulmonary circulation responds to hypoxia with vasoconstriction, a mechanism that
helps to adapt to short-lived hypoxic episodes. When sustained, hypoxic pulmonary …

Exposure to hypoxia elicits widespread physiological responses that are critical for
successful acclimatization; however, these responses may induce apparent maladaptive …

In healthy vascular endothelium, nitric oxide acts as a vasodilator paracrine mediator on
adjacent smooth muscle cells. By activating soluble guanylyl cyclase, nitric oxide stimulates …

High-altitude exposure typically reduces endothelial function, and this is modulated by
hemoconcentration resulting from plasma volume contraction. However, the specific impact …

Background: Prolonged exposure to altitude-associated chronic hypoxia (CH) may cause
high-altitude pulmonary hypertension (HAPH). Chronic intermittent hypobaric hypoxia (CIH) …

Intermittent (IH), as opposed to continuous hypoxia (CH), is thought to have beneficial effects
on cardiovascular function and health. In the present study, we examined the acute effects of …

The purpose of this study is to assess the production of nitric oxide in professional cross-
country skiers with normotensive and hypertensive responses to physical activity at …

The study of conduit artery endothelial adaptation to hypoxia has been restricted to the
brachial artery, and comparisons with highlanders have been confounded by differences in …

High altitude‐induced hypoxaemia is often associated with peripheral vascular dysfunction.
However, the basic mechanism (s) underlying high‐altitude vascular impairments remains …