Structural chemistry of peptides containing backbone expanded amino acid residues: conformational features of β, γ, and hybrid peptides
PG Vasudev, S Chatterjee, N Shamala… - Chemical …, 2011 - ACS Publications
The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …
Endogenous opiates and behavior: 2005
RJ Bodnar, GE Klein - Peptides, 2006 - Elsevier
This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …
the endogenous opioid system, now spanning over a quarter-century of research. It …
Peptides containing β-amino acid patterns: challenges and successes in medicinal chemistry
The construction of bioactive peptides using β-amino acid-containing sequence patterns is a
very promising strategy to obtain analogues that exhibit properties of high interest for …
very promising strategy to obtain analogues that exhibit properties of high interest for …
Peptidomimetics and their applications for opioid peptide drug discovery
YS Lee - Biomolecules, 2022 - mdpi.com
Despite various advantages, opioid peptides have been limited in their therapeutic uses due
to the main drawbacks in metabolic stability, blood-brain barrier permeability, and …
to the main drawbacks in metabolic stability, blood-brain barrier permeability, and …
Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs
WX Liu, R Wang - Medicinal research reviews, 2012 - Wiley Online Library
The application of endomorphins as clinical available analgesic drugs has been impeded by
their relatively poor receptor selectivity compared with alkaloid analgesics, rapid …
their relatively poor receptor selectivity compared with alkaloid analgesics, rapid …
A new class of highly potent and selective endomorphin-1 analogues containing α-methylene-β-aminopropanoic acids (map)
Y Wang, Y Xing, X Liu, H Ji, M Kai, Z Chen… - Journal of medicinal …, 2012 - ACS Publications
A new class of endomorphin-1 (EM-1) analogues were synthesized by introduction of novel
unnatural α-methylene-β-amino acids (Map) at position 3 or/and position 4. Their binding …
unnatural α-methylene-β-amino acids (Map) at position 3 or/and position 4. Their binding …
Design, synthesis, and pharmacological characterization of novel endomorphin-1 analogues as extremely potent μ-opioid agonists
X Liu, Y Wang, Y Xing, J Yu, H Ji, M Kai… - Journal of Medicinal …, 2013 - ACS Publications
Recently we reported the synthesis and structure–activity study of endomorphin-1 (EM-1)
analogues containing novel, unnatural α-methylene-β-aminopropanoic acids (Map). In the …
analogues containing novel, unnatural α-methylene-β-aminopropanoic acids (Map). In the …
Catalytic, One-pot synthesis of β-amino acids from α-amino acids. Preparation of α, β-peptide derivatives
C Saavedra, R Hernández, A Boto… - The Journal of Organic …, 2009 - ACS Publications
The one-pot conversion of readily available α-amino acid into β-amino acid derivatives was
carried out in good yields. The method is a sequential process initiated by a tandem radical …
carried out in good yields. The method is a sequential process initiated by a tandem radical …
Constraining endomorphin-1 by β, α-hybrid dipeptide/heterocycle scaffolds: identification of a novel κ-opioid receptor selective partial agonist
R De Marco, A Bedini, S Spampinato… - Journal of Medicinal …, 2018 - ACS Publications
Herein we present the expedient synthesis of endomorphin-1 analogues containing
stereoisomeric β2-homo-Freidinger lactam-like scaffolds ([Amo2] EM), and we discuss …
stereoisomeric β2-homo-Freidinger lactam-like scaffolds ([Amo2] EM), and we discuss …
Using β-amino acids and β-peptide templates to create bioactive ligands and biomaterials
MP Del Borgo, K Kulkarni… - Current pharmaceutical …, 2017 - ingentaconnect.com
β-Amino acids are being increasingly used in the design of bioactive ligands and more
recently in the generation of novel biomaterials. Peptides containing either individual β …
recently in the generation of novel biomaterials. Peptides containing either individual β …