Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

The global burden of neurodegenerative diseases underscores the urgent need for
innovative strategies to define new drug targets and disease-modifying factors. The …

Mitochondria and the endoplasmic reticulum (ER) form tight structural associations and
these facilitate a number of cellular functions. However, the mechanisms by which regions of …

L-lactate was long considered a glycolytic by-product but is now being recognized as a
signaling molecule involved in cell survival. In this manuscript, we report the role of L-lactate …

Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

Mutations in the TAR DNA B inding P rotein gene (TARDBP), encoding the protein TDP‐43,
were identified in amyotrophic lateral sclerosis (ALS) patients. Interestingly, TDP‐43 positive …

Therapeutic drug development is a long, expensive, and complex process that usually takes
12–15 years. In the early phases of drug discovery, in particular, there is a growing need for …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is
characterized by selective loss of motor neurons in brain and spinal cord. TAR DNA‐binding …

An expansion of the hexanucleotide GGGGCC repeat in the first intron of C9ORF72 gene
was recently linked to amyotrophic lateral sclerosis. It is not known if the mutation results in a …

Mutation of Tar DNA‐binding protein 43 (TDP‐43) is linked to amyotrophic lateral sclerosis.
Although astrocytes have important roles in neuron function and survival, their potential …