Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of
gene expression. This is especially true in the cancer setting, as many oncogenes and …

The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a
downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes …

Remarkable progress has been made in defining a new understanding of the role of mRNA
translation and protein synthesis in human cancer. Translational control is a crucial …

The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for
gene expression, and occurs principally at the initiation phase which is mainly regulated by …

Background Olaparib has single-agent activity against breast/ovarian cancer (BrCa/OvCa) in
germline BRCA1 or BRCA2 mutation carriers (gBRCAm). We hypothesized addition of …

Recent advances in understanding the role of eukaryotic translation initiator factor 4E
(eIF4E) in tumorigenesis and cancer progression have generated significant interest in …

Abstract Human mRNA DeXD/H-box helicases are ubiquitous molecular motors that are
required for the majority of cellular processes that involve RNA metabolism. One of the most …

Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast
cancer following invasive ductal carcinoma (IDC). ILC differs from IDC in a number of …