CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells
Serine/threonine kinases called cyclin-dependent kinases (CDKs) interact with cyclins and
CDK inhibitors (CKIs) to control the catalytic activity. CDKs are essential controllers of RNA …
CDK inhibitors (CKIs) to control the catalytic activity. CDKs are essential controllers of RNA …
Tipping the balance: toward rational combination therapies to overcome venetoclax resistance in mantle cell lymphoma
YJ Thus, E Eldering, AP Kater, M Spaargaren - Leukemia, 2022 - nature.com
Mantle cell lymphoma (MCL), an aggressive, but incurable B-cell lymphoma, is genetically
characterized by the t (11; 14) translocation, resulting in the overexpression of Cyclin D1. In …
characterized by the t (11; 14) translocation, resulting in the overexpression of Cyclin D1. In …
[HTML][HTML] Targeting cancer hallmarks with epigallocatechin gallate (EGCG): mechanistic basis and therapeutic targets
Epigallocatechin gallate (EGCG) is a catechin, which is a type of flavonoid found in high
concentrations in green tea. EGCG has been studied extensively for its potential health …
concentrations in green tea. EGCG has been studied extensively for its potential health …
The regulation of cyclins and cyclin-dependent kinases in the development of gastric cancer
A Javed, M Yarmohammadi, KS Korkmaz… - International Journal of …, 2023 - mdpi.com
Gastric cancer predominantly occurs in adenocarcinoma form and is characterized by
uncontrolled growth and metastases of gastric epithelial cells. The growth of gastric cells is …
uncontrolled growth and metastases of gastric epithelial cells. The growth of gastric cells is …
Plant-derived sulforaphane suppresses growth and proliferation of drug-sensitive and drug-resistant bladder cancer cell lines in vitro
H Xie, J Rutz, S Maxeiner, T Grein, A Thomas… - Cancers, 2022 - mdpi.com
Simple Summary The natural compound sulforaphane is highly popular among tumor
patients, since it is suggested to prevent oncogenesis and cancer progression. However …
patients, since it is suggested to prevent oncogenesis and cancer progression. However …
Cyclin-dependent kinases in cancer: Role, regulation, and therapeutic targeting
Regulated cell division is one of the fundamental phenomena which is the basis of all life on
earth. Even a single base pair mutation in DNA leads to the production of the dysregulated …
earth. Even a single base pair mutation in DNA leads to the production of the dysregulated …
Cyclin-dependent kinase 4/6 inhibitors and dermatologic adverse events: results from the EADV task force “Dermatology for Cancer Patients” International Study
P Sollena, N Vasiliki, E Kotteas, AJ Stratigos, D Fattore… - Cancers, 2023 - mdpi.com
Simple Summary Treatment with cyclin-dependent kinase 4/6 inhibitor (CDK4/6i), has
demonstrated significantly improved progression-free survival in patients with hormone …
demonstrated significantly improved progression-free survival in patients with hormone …
The role of CDK pathway dysregulation and its therapeutic potential in soft tissue sarcoma
JT Thiel, A Daigeler, J Kolbenschlag, K Rachunek… - Cancers, 2022 - mdpi.com
Simple Summary Soft tissue sarcomas (STSs) are rare malignant conditions with more than
70 subtypes that are difficult to treat, especially in advanced or metastatic states. Recently …
70 subtypes that are difficult to treat, especially in advanced or metastatic states. Recently …
Identification of natural marine compounds as potential inhibitors of CDK2 using molecular docking and molecular dynamics simulation approach
The multifunctional enzyme cyclin-dependent kinase 2 (CDK2) protein is essential for cell
proliferation, transcription and modulation of the cell cycle. There is a dysfunction that is …
proliferation, transcription and modulation of the cell cycle. There is a dysfunction that is …
Semaphorin 6C suppresses proliferation of pancreatic cancer cells via inhibition of the AKT/GSK3/β-catenin/cyclin D1 pathway
YH Hung, SH Hsu, YC Hou, PY Chu, YY Su… - International journal of …, 2022 - mdpi.com
Semaphorins (SEMAs) are axon guidance factors that participate in axonal connections and
nerve system development. However, the functional roles of SEMAs in tumorigenesis are …
nerve system development. However, the functional roles of SEMAs in tumorigenesis are …