A review on bioactive iridoids in edible fruits–from garden to food and pharmaceutical products

D Przybylska, AZ Kucharska… - Food Reviews …, 2023 - Taylor & Francis
Iridoids are natural monoterpenoids, widely distributed in ornamental plants, herbs, and
medicinal plants, but particularly in the green parts of plants. Their significance arises from …

[HTML][HTML] Antitumor potential of Hedyotis diffusa Willd: a systematic review of bioactive constituents and underlying molecular mechanisms

X Han, X Zhang, Q Wang, L Wang, S Yu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cancer is a major cause of death in the world. Chemotherapy can extend the life of cancer
patients to some extent, but the quality of life is reduced. Therefore, the quest for more …

Asperuloside alleviates lipid accumulation and inflammation in HFD-induced NAFLD via AMPK signaling pathway and NLRP3 inflammasome

Q Shen, Y Chen, J Shi, C Pei, S Chen, S Huang… - European Journal of …, 2023 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is a clinical pathological syndrome of
hepatic parenchymal cell steatosis caused by excessive lipid deposition, which is the …

Asperuloside inhibited epithelial-mesenchymal transition in colitis associated cancer via activation of vitamin D receptor

Y Lu, T Guan, S Xu, Y Chen, Q Shen, S Zhu, Y Liu… - Phytomedicine, 2022 - Elsevier
Background: Asperuloside is a natural compound extracted from various herbs with several
bioactivities. Its effects on anti-inflammation and anti-tumor indicated that asperuloside might …

Metabolomic profiling and immunomodulatory activity of a polyherbal combination in cyclophosphamide-induced immunosuppressed mice

S Zahiruddin, A Parveen, W Khan, M Ibrahim… - Frontiers in …, 2022 - frontiersin.org
The study was aimed to develop a characterized polyherbal combination as an
immunomodulator containing Phyllanthus emblica L., Piper nigrum L., Withania somnifera …

Asperuloside as a Novel NRF2 Activator to Ameliorate Endothelial Dysfunction in High Fat Diet-Induced Obese Mice

C He, R Zhu, L He, CYB Chook, H Li… - Antioxidants & Redox …, 2024 - liebertpub.com
Aims: Current treatments are inadequate in alleviating obesity-associated vascular
diseases. The development of effective therapies to ameliorate endothelial dysfunction and …

Extracts of Knoxia roxburghii (Spreng.) MA Rau Induce Apoptosis in Human MCF-7 Breast Cancer Cells via Mitochondrial Pathways

XJ Chen, XY Pu, XM Pu, X Li, ZB Liu, MJ Mei, XG Wang… - Molecules, 2022 - mdpi.com
Knoxia roxburghii (Spreng.) MA Rau (KR) is a plant clinically used in traditional Chinese
medicine (TCM) for the treatment of cancer. The study objectives were to examine the effects …

Antioxidant Effect of Lonicera caerulea L. in the Cardiovascular System of Obese Zucker Rats

E Dayar, M Cebova, J Lietava, E Panghyova… - Antioxidants, 2021 - mdpi.com
Lonicera caerulea L.(Loni) represents a promising source of beneficial polyphenols with
therapeutical potential in cardiovascular diseases. We aimed to study the effects of Loni and …

Identification of novel cannabinoid CB2 receptor agonists from botanical compounds and preliminary evaluation of their anti-osteoporotic effects

SJ Hu, G Cheng, H Zhou, Q Zhang, QL Zhang, Y Wang… - Molecules, 2022 - mdpi.com
As cannabinoid CB2 receptors (CB2R) possess various pharmacological effects—including
anti-epilepsy, analgesia, anti-inflammation, anti-fibrosis, and regulation of bone metabolism …

Asperuloside attenuates cadmium-induced toxicity by inhibiting oxidative stress, inflammation, fibrosis and apoptosis in rats

Z Kong, C Liu, OJ Olatunji - Scientific Reports, 2023 - nature.com
This present study investigated the protective effects of asperuloside (ASP) against cadmium-
induced nephrocardiac toxicity. Rats were treated with 50 mg/kg of ASP for five weeks and …