Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …

All genes interact with other genes, and their additive effects and epistatic interactions affect
an organism's phenotype and fitness. Recent theoretical and empirical work has advanced …

Adequate representations of protein evolution should consider how the acceptance of
mutations depends on the sequence context in which they arise. However, epistatic …

Developmental system drift is a likely mechanism for the origin of hybrid incompatibilities
between closely related species. We examine here the detailed mechanistic basis of hybrid …

Crosses between closely related animal species often result in male hybrids that are sterile,
and the molecular and functional basis of genetic factors for hybrid male sterility is of great …

Speciation is fundamental to the process of generating the huge diversity of life on Earth.
However, we are yet to have a clear understanding of its molecular-genetic basis. Here, we …

We report a new mechanism for allelic dominance in regulatory genetic interactions that we
call binding dominance. We investigated a biophysical model of gene regulation, where the …

Mutations in DNA sequences that bind transcription factors and thus modulate gene
expression are a source of adaptive variation in gene expression. To understand how …

Dobzhansky and Muller proposed a general mechanism through which microevolution, the
substitution of alleles within populations, can cause the evolution of reproductive isolation …

Realistic fitness landscapes generally display a redundancy-fitness trade-off: highly fit trait
configurations are inevitably rare, while less fit trait configurations are expected to be more …