The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …

The plasma membrane allows the cell to sense and adapt to changes in the extracellular
environment by relaying external inputs via intracellular signaling networks. One central …

One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production …

Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected
insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory …

The life cycle of a primary cilium begins in quiescence and ends prior to mitosis. In quiescent
cells, the primary cilium insulates itself from contiguous dynamic membrane processes on …

BACKGROUND How do the different cell types in our bodies maintain their distinctive and
characteristic sizes? Although much is known about the signaling networks that stimulate or …

The primary cilium is an antenna-like, immotile organelle present on most types of
mammalian cells, which interprets extracellular signals that regulate growth and …

An adult animal consists of cells of vastly different size and activity, but the regulation of cell
size remains poorly understood. Recent studies uncovering some of the signaling pathways …

Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary
cilia. The recently discovered role of primary cilia in nutrient sensing and signalling …

After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …