Oxalate homeostasis is maintained through a delicate balance between endogenous
sources, exogenous supply and excretion from the body. Novel studies have shed light on …

The ten-member SLC26 gene family encodes anion exchangers capable of transporting a
wide variety of monovalent and divalent anions. The physiological role (s) of individual …

Pendred syndrome is a recessively inherited disorder with the hallmark features of
congenital deafness and thyroid goitre. By some estimates, the disorder may account for …

Pendred syndrome is the most common form of syndromic deafness and characterized by
congenital sensorineural hearing loss and goitre 1, 2, 3. This disorder was mapped to …

BACKGROUND & AIMS:: Intestinal-type gastric cancer is often preceded by intestinal
metaplasia in humans. The genetic events responsible for the transdifferentiation that occurs …

A major transport function of the human intestine involves the absorption of chloride in
exchange for bicarbonate1. We have studied a recessively inherited defect of this exchange …

Epidemiologic studies have demonstrated variations in the incidence of colon cancer
between populations and socioeconomic groups. Differences in dietary habits have been …

A cDNA encoding a high‐affinity sulphate transporter has been isolated from barley by
complementation of a yeast mutant. The cDNA, designated HVST1, encodes a polypeptide …

All cells require inorganic sulfate for normal function. Sulfate is among the most important
macronutrients in cells and is the fourth most abundant anion in human plasma (300 μM) …

The identities of the apical Cl−/base exchangers in kidney proximal tubule and cortical
collecting duct (CCD) cells remain unknown. Pendrin (PDS), which is expressed at high …