It has been 200 years since Parkinson disease (PD) was described by Dr. Parkinson in
1817. The disease is the second most common neurodegenerative disease characterized …

Neuronal loss is one of the striking causes of various central nervous system (CNS)
disorders, including major neurodegenerative diseases, such as Alzheimer's disease (AD) …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Sustaining neuronal proteostasis during the course of our life is a central aspect required for
brain function. The dynamic nature of synaptic composition and abundance is a requisite to …

The unfolded protein response (UPR) is a highly conserved protein quality control
mechanism, activated in response to Endoplasmic Reticulum (ER) stress. Signalling is …

In eukaryotic cells, the endoplasmic reticulum (ER) is the cell compartment involved in
secretory protein translocation and quality control of secretory protein folding. Different …

Recessive loss-of-function mutations in ATP13A2 (PARK9) are associated with a spectrum
of neurodegenerative disorders, including Parkinson's disease (PD). We recently revealed …

Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading
to the progressive decline of motor control due to the loss of dopaminergic neurons in the …

Despite decades of research, current therapeutic interventions for Parkinson's disease (PD)
are insufficient as they fail to modify disease progression by ameliorating the underlying …

Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …