Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

The BRCA1–BARD1 tumour suppressor is an E3 ubiquitin ligase necessary for the repair of
DNA double-strand breaks by homologous recombination,,,,,,,,–. The BRCA1–BARD1 …

The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …

Post-translational modifications of histones regulate all DNA-templated processes, including
replication, transcription and repair. These modifications function as platforms for the …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …

BRD4, the most extensively studied member of the BET family, is an epigenetic regulator
that localizes to DNA via binding to acetylated histones and controls the expression of …

The recognition of modified histones by" reader" proteins constitutes a key mechanism
regulating gene expression in the chromatin context. Compared with the great variety of …

Nucleosome assembly following DNA replication, DNA repair and gene transcription is
critical for the maintenance of genome stability and epigenetic information. Nucleosomes …