Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells
Human organoids are emerging as a valuable resource to investigate human organ
development and disease. The applicability of human organoids has been limited, partly …
development and disease. The applicability of human organoids has been limited, partly …
Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary
Organogenesis is a complex and interconnected process that is orchestrated by multiple
boundary tissue interactions,,,,,–. However, it remains unclear how individual, neighbouring …
boundary tissue interactions,,,,,–. However, it remains unclear how individual, neighbouring …
Making it new again: insight into liver development, regeneration, and disease from zebrafish research
The adult liver of most vertebrates is predominantly comprised of hepatocytes. However,
these cells must work in concert with biliary, stellate, vascular, and immune cells to …
these cells must work in concert with biliary, stellate, vascular, and immune cells to …
[HTML][HTML] Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish
Thiabendazole, a benzimidazole fungicide, is widely used to prevent yield loss in
agricultural land by inhibiting plant diseases derived from fungi. As thiabendazole has a …
agricultural land by inhibiting plant diseases derived from fungi. As thiabendazole has a …
Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity
Q Zheng, J Tang, A Aicher, T Bou Kheir… - Journal of Experimental …, 2023 - Springer
Background Pancreatic ductal adenocarcinoma (PDAC) is a profoundly aggressive and fatal
cancer. One of the key factors defining its aggressiveness and resilience against …
cancer. One of the key factors defining its aggressiveness and resilience against …
CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant
Functional enhancer annotation is critical for understanding tissue-specific transcriptional
regulation and prioritizing disease-associated non-coding variants. However, unbiased …
regulation and prioritizing disease-associated non-coding variants. However, unbiased …
ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers
R Yelagandula, K Stecher, M Novatchkova… - Nature cell …, 2023 - nature.com
ZNF462 haploinsufficiency is linked to Weiss–Kruszka syndrome, a genetic disorder
characterized by neurodevelopmental defects, including autism. Though conserved in …
characterized by neurodevelopmental defects, including autism. Though conserved in …
Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood
O Weeks, GD Bossé, IM Oderberg… - The Journal of …, 2020 - Am Soc Clin Investig
Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the
development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there …
development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there …
Mevinphos induces developmental defects via inflammation, apoptosis, and altered MAPK and Akt signaling pathways in zebrafish
Mevinphos, an organophosphate insecticide, is widely used to control pests and enhance
crop yield. Because of its high solubility, it can easily flow into water and threaten the aquatic …
crop yield. Because of its high solubility, it can easily flow into water and threaten the aquatic …
Nuclear receptor subfamily 5 group A member 2 (NR5A2): role in health and diseases
N Sandhu, S Rana, K Meena - Molecular Biology Reports, 2021 - Springer
Nuclear receptors are the regulatory molecules that mediate cellular signals as they interact
with specific DNA sequences. NR5A2 is a member of NR5A subfamily having four members …
with specific DNA sequences. NR5A2 is a member of NR5A subfamily having four members …