Neutralizing efficacy of encapsulin nanoparticles against SARS-CoV2 variants of concern

S Khaleeq, N Sengupta, S Kumar, UR Patel… - Viruses, 2023 - mdpi.com
Rapid emergence of the SARS-CoV-2 variants has dampened the protective efficacy of
existing authorized vaccines. Nanoparticle platforms offer a means to improve vaccine …

Use of virus-like particles and nanoparticle-based vaccines for combating picornavirus infections

M Ren, SW Abdullah, C Pei, H Guo, S Sun - Veterinary Research, 2024 - Springer
Picornaviridae are non-enveloped ssRNA viruses that cause diseases such as poliomyelitis,
hand-foot-and-mouth disease (HFMD), hepatitis A, encephalitis, myocarditis, and foot-and …

Protein Nanoparticles as Vaccine Platforms for Human and Zoonotic Viruses

KK Pandey, BR Sahoo, AK Pattnaik - Viruses, 2024 - mdpi.com
Vaccines are one of the most effective medical interventions, playing a pivotal role in treating
infectious diseases. Although traditional vaccines comprise killed, inactivated, or live …

Heterologous Prime-Boost with Immunologically Orthogonal Protein Nanoparticles for Peptide Immunofocusing

S Bhattacharya, MC Jenkins, P Keshavarz-Joud… - ACS …, 2024 - ACS Publications
Protein nanoparticles are effective platforms for antigen presentation and targeting effector
immune cells in vaccine development. Encapsulins are a class of protein-based microbial …

Molecular features of the serological IgG repertoire elicited by egg-based, cell-based, or recombinant haemagglutinin-based seasonal influenza vaccines: a …

J Park, F Bartzoka, T von Beck, ZN Li, M Mishina… - The Lancet …, 2024 - thelancet.com
Background Egg-based inactivated quadrivalent seasonal influenza vaccine (eIIV4), cell
culture-based inactivated quadrivalent seasonal influenza vaccine (ccIIV4), and …

A Self-Assembling Pfs230D1-Ferritin Nanoparticle Vaccine Has Potent and Durable Malaria Transmission-Reducing Activity

ND Salinas, R Ma, H McAleese, T Ouahes, CA Long… - Vaccines, 2024 - mdpi.com
Malaria is caused by eukaryotic protozoan parasites of the genus Plasmodium. There are
249 million new cases and 608,000 deaths annually, and new interventions are desperately …

Cryo-EM reveals the mechanism of DNA compaction by Mycobacterium smegmatis Dps2

P Garg, T Satheesh, M Ganji, S Dutta - Journal of Molecular Biology, 2024 - Elsevier
DNA binding protein from starved cells (Dps) is a miniature ferritin complex, which plays a
vital role in protecting bacterial DNA during starvation to maintain the integrity of bacteria …

Protein Nanoparticles as Viral Vaccine Platforms

KK Pandey, BR Sahoo, AK Pattnaik - 2024 - preprints.org
Vaccines are one of the most effective medical interventions, playing a pivotal role in treating
infectious diseases. Although traditional vaccines comprising of killed, inactivated, or live …

Vaccine Research and Development in India for COVID-19 and Influenza

K Kanjo, G Chakshusmathi, R Varadarajan - Biotechnology in India …, 2024 - Springer
The COVID-19 pandemic has clearly demonstrated that respiratory viruses can cause
immense loss of lives and livelihoods. India is the home to some of the world's largest …

Biochemical and biophysical characterisation of Thermotoga maritima and Myxococcus xanthus encapsulins towards biotechnology applications

A Van De Steen - 2023 - discovery.ucl.ac.uk
As synthetic systems become multi-levelled, spatial control of biomolecules is increasingly
important for sub-cellular and in vitro applications. Protein compartments such as encapsulin …