Prefrontal cortical regulation of fear learning
The prefrontal cortex regulates the expression of fear based on previously learned
information. Recently, this brain area has emerged as being crucial in the initial formation of …
information. Recently, this brain area has emerged as being crucial in the initial formation of …
Bridging the interval: theory and neurobiology of trace conditioning
JD Raybuck, KM Lattal - Behavioural processes, 2014 - Elsevier
An early finding in the behavioral analysis of learning was that conditioned responding
weakens as the conditioned stimulus (CS) and unconditioned stimulus (US) are separated …
weakens as the conditioned stimulus (CS) and unconditioned stimulus (US) are separated …
Prefrontal activity links nonoverlapping events in memory
The medial prefrontal cortex (mPFC) plays an important role in memory. By maintaining a
working memory buffer, neurons in prelimbic (PL) mPFC may selectively contribute to …
working memory buffer, neurons in prelimbic (PL) mPFC may selectively contribute to …
Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial …
Trace fear conditioning, in which a brief empty “trace interval” occurs between presentation
of the CS and UCS, differs from standard delay conditioning in that contributions from both …
of the CS and UCS, differs from standard delay conditioning in that contributions from both …
Ventral hippocampal input to the prelimbic cortex dissociates the context from the cue association in trace fear memory
RC Twining, K Lepak, AJ Kirry… - Journal of …, 2020 - Soc Neuroscience
The PFC, through its high degree of interconnectivity with cortical and subcortical brain
areas, mediates cognitive and emotional processes in support of adaptive behaviors. This …
areas, mediates cognitive and emotional processes in support of adaptive behaviors. This …
Functional network of contextual and temporal memory has increased amygdala centrality and connectivity with the retrosplenial cortex, thalamus, and hippocampus
TB Santos, JC Kramer-Soares… - Scientific Reports, 2023 - nature.com
In fear conditioning with time intervals between the conditioned (CS) and unconditioned
(US) stimuli, a neural representation of the CS must be maintained over time to be …
(US) stimuli, a neural representation of the CS must be maintained over time to be …
Common brain activations for painful and non-painful aversive stimuli
DJ Hayes, G Northoff - BMC neuroscience, 2012 - Springer
Background Identification of potentially harmful stimuli is necessary for the well-being and
self-preservation of all organisms. However, the neural substrates involved in the processing …
self-preservation of all organisms. However, the neural substrates involved in the processing …
NR2A-and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning
Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal
cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear …
cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear …
Reactivation of encoding ensembles in the prelimbic cortex supports temporal associations
TB Santos, CA de Oliveira Coelho… - …, 2024 - nature.com
Fear conditioning is encoded by strengthening synaptic connections between the neurons
activated by a conditioned stimulus (CS) and those activated by an unconditioned stimulus …
activated by a conditioned stimulus (CS) and those activated by an unconditioned stimulus …
Pituitary adenylate cyclase-activating polypeptide (PACAP) signaling in the prefrontal cortex modulates cued fear learning, but not spatial working memory, in female …
AJ Kirry, MR Herbst, SE Poirier, MM Maskeri… - …, 2018 - Elsevier
A genetic polymorphism within the gene encoding the pituitary adenylate cyclase-activating
polypeptide (PACAP) receptor type I (PAC1R) has recently been associated with hyper …
polypeptide (PACAP) receptor type I (PAC1R) has recently been associated with hyper …