Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and
leukotrienes, impact the immune system, usually as proinflammatory factors. Other …

ABSTRACT TLR3 belong to the Toll-like receptors family, it is mainly expressed on immune
cells where it senses pathogen-associated molecular patterns and initiates innate immune …

Reinvigoration of antitumor immunity remains an unmet challenge. Our retrospective
analyses revealed that cancer patients who took antihistamines during immunotherapy …

In the present review, we will discuss the recent advances in the understanding of the role of
histamine and histamine receptors in cancer biology. The controversial role of the …

High levels of histamine and histamine receptors (HRs), including H1R~ H4R, are found in
many different types of tumor cells and cells in the tumor microenvironment, suggesting their …

Background We have previously shown an association with substantially improved survival
in breast cancer and melanoma for desloratadine and loratadine users, and set out to find …

Preclinical, clinical, and epidemiological studies indicate that vitamin D3 (VD) deficiency is a
risk factor for the development of breast cancer. Underlying mechanisms include the ability …

Cancer is the second leading cause of death globally and its incidence and mortality are
rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells …

Highlights•Single-cell sequencing reveals enormous macrophage complexity.•Strong
functional imprinting of tumor-associated macrophages by tumor microenvironment.• …

Background and Purpose: Drug repositioning is a promising strategy for discovering new
therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their …