Subarachnoid haemorrhage (SAH) is the third most common subtype of stroke. Incidence
has decreased over past decades, possibly in part related to lifestyle changes such as …

Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …

Our brains consist of 80% water, which is continuously shifted between different
compartments and cell types during physiological and pathophysiological processes …

Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

Abstract Purpose of Review Aneurysmal subarachnoid hemorrhage remains a devastating
disease process despite medical advances made over the past 3 decades. Much of the …

For patients who survive the initial bleeding event of a ruptured brain aneurysm, delayed
cerebral ischemia (DCI) is one of the most important causes of mortality and poor …

Status epilepticus (SE) treatment strategies vary substantially from one institution to another
due to the lack of data to support one treatment over another. To provide guidance for the …

A modern understanding of how cerebral cortical lesions develop after acute brain injury is
based on Aristides Leão's historic discoveries of spreading depression and asphyxial/anoxic …

Abstract Purpose of Review Delayed cerebral ischemia (DCI) is common after subarachnoid
hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was …

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these
cells control blood flow is crucial for understanding how neural computation is powered, for …