Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease
D Goldblatt, G Alter, S Crotty… - Immunological reviews, 2022 - Wiley Online Library
Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐
CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays …
CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays …
Vaccination induces HIV broadly neutralizing antibody precursors in humans
Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …
B cell activation and response regulation during viral infections
JH Lam, FL Smith, N Baumgarth - Viral immunology, 2020 - liebertpub.com
Acute viral infections are characterized by rapid increases in viral load, leading to cellular
damage and the resulting induction of complex innate and adaptive antiviral immune …
damage and the resulting induction of complex innate and adaptive antiviral immune …
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence
GE Hartley, ESJ Edwards, PM Aui, N Varese… - Science …, 2020 - science.org
Lasting immunity following SARS-CoV-2 infection is questioned because serum antibodies
decline in convalescence. However, functional immunity is mediated by long-lived memory T …
decline in convalescence. However, functional immunity is mediated by long-lived memory T …
The expansion of human T-bethighCD21low B cells is T cell dependent
B Keller, V Strohmeier, I Harder, S Unger… - Science …, 2021 - science.org
Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …
activation of the adaptive immune system in certain infections and autoimmune disorders …
S protein-reactive IgG and memory B cell production after human SARS-CoV-2 infection includes broad reactivity to the S2 subunit
P Nguyen-Contant, AK Embong, P Kanagaiah… - MBio, 2020 - Am Soc Microbiol
The high susceptibility of humans to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection, the cause of coronavirus disease 2019 (COVID-19), reflects the …
(SARS-CoV-2) infection, the cause of coronavirus disease 2019 (COVID-19), reflects the …
Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans
The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans
SF Andrews, LY Cominsky, GD Shimberg… - Science Translational …, 2023 - science.org
Current yearly seasonal influenza vaccines primarily induce an antibody response directed
against the immunodominant but continually diversifying hemagglutinin (HA) head region …
against the immunodominant but continually diversifying hemagglutinin (HA) head region …
The transcription factor T-bet resolves memory B cell subsets with distinct tissue distributions and antibody specificities in mice and humans
JL Johnson, RL Rosenthal, JJ Knox, A Myles… - Immunity, 2020 - cell.com
B cell subsets expressing the transcription factor T-bet are associated with humoral immune
responses and autoimmunity. Here, we examined the anatomic distribution, clonal …
responses and autoimmunity. Here, we examined the anatomic distribution, clonal …