The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without
curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial …

Background and Purpose Tetramethylpyrazine (TMP) was originally isolated from the
traditional Chinese herb ligusticum and the fermented Japanese food natto and has since …

Pulmonary arterial hypertension (PAH) is a severe and multifactorial disease. PAH
pathogenesis mostly involves pulmonary arterial endothelial and pulmonary arterial smooth …

Background/Aims: The proliferation of human bronchial smooth muscle cells (HBSMCs) is a
key pathophysiological component of airway remodeling in chronic obstructive pulmonary …

Background: Mutations in NFATc1 and BMP-2 genes result in bone abnormalities in mice.
Results: BMP-2 activates intracellular Ca 2+ release, thus activating calcineurin …

Hypoxic Pulmonary Vasoconstriction (HPV) is an important physiological mechanism of the
lungs that matches perfusion to ventilation thus maximizing O2 saturation of the venous …

The dysregulation of K+ channels is a hallmark of pulmonary arterial hypertension (PAH).
Herein, the channelome was analyzed in lungs of patients with PAH in a public …

Intracranial aneurysm (IA) is a frequent cerebrovascular disorder with unclear pathogenesis.
The vascular smooth muscle cells (VSMCs) phenotypic switch is essential for IA formation. It …

Calcium phosphate (CaP) crystals are formed in pathological calcification as well as during
stone formation. Although there are several theories as to how these crystals can develop …