Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
B Nilius, A Szallasi - Pharmacological reviews, 2014 - ASPET
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Ion channels in pulmonary hypertension: a therapeutic interest?
M Lambert, V Capuano, A Olschewski… - International journal of …, 2018 - mdpi.com
Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without
curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial …
curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial …
Tetramethylpyrazine: a promising drug for the treatment of pulmonary hypertension
Background and Purpose Tetramethylpyrazine (TMP) was originally isolated from the
traditional Chinese herb ligusticum and the fermented Japanese food natto and has since …
traditional Chinese herb ligusticum and the fermented Japanese food natto and has since …
Role of Store-Operated Ca2+ Entry in the Pulmonary Vascular Remodeling Occurring in Pulmonary Arterial Hypertension
B Masson, D Montani, M Humbert, V Capuano… - Biomolecules, 2021 - mdpi.com
Pulmonary arterial hypertension (PAH) is a severe and multifactorial disease. PAH
pathogenesis mostly involves pulmonary arterial endothelial and pulmonary arterial smooth …
pathogenesis mostly involves pulmonary arterial endothelial and pulmonary arterial smooth …
[HTML][HTML] Nicotine-induced airway smooth muscle cell proliferation involves TRPC6-dependent calcium influx via α7 nAChR
W Hong, G Peng, B Hao, B Liao, Z Zhao… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: The proliferation of human bronchial smooth muscle cells (HBSMCs) is a
key pathophysiological component of airway remodeling in chronic obstructive pulmonary …
key pathophysiological component of airway remodeling in chronic obstructive pulmonary …
Bone morphogenetic protein-2 (BMP-2) activates NFATc1 transcription factor via an autoregulatory loop involving Smad/Akt/Ca2+ signaling
Background: Mutations in NFATc1 and BMP-2 genes result in bone abnormalities in mice.
Results: BMP-2 activates intracellular Ca 2+ release, thus activating calcineurin …
Results: BMP-2 activates intracellular Ca 2+ release, thus activating calcineurin …
Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung
PP Jain, S Hosokawa, M Xiong… - Pulmonary …, 2020 - journals.sagepub.com
Hypoxic Pulmonary Vasoconstriction (HPV) is an important physiological mechanism of the
lungs that matches perfusion to ventilation thus maximizing O2 saturation of the venous …
lungs that matches perfusion to ventilation thus maximizing O2 saturation of the venous …
Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
F Perez-Vizcaino, A Cogolludo… - Scientific Reports, 2021 - nature.com
The dysregulation of K+ channels is a hallmark of pulmonary arterial hypertension (PAH).
Herein, the channelome was analyzed in lungs of patients with PAH in a public …
Herein, the channelome was analyzed in lungs of patients with PAH in a public …
[HTML][HTML] Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm
ZH Sun, F Liu, LL Kong, PM Ji, L Huang… - Biomedicine & …, 2023 - Elsevier
Intracranial aneurysm (IA) is a frequent cerebrovascular disorder with unclear pathogenesis.
The vascular smooth muscle cells (VSMCs) phenotypic switch is essential for IA formation. It …
The vascular smooth muscle cells (VSMCs) phenotypic switch is essential for IA formation. It …
Vascular calcification and stone disease: a new look towards the mechanism
AJ Yiu, D Callaghan, R Sultana… - Journal of …, 2015 - mdpi.com
Calcium phosphate (CaP) crystals are formed in pathological calcification as well as during
stone formation. Although there are several theories as to how these crystals can develop …
stone formation. Although there are several theories as to how these crystals can develop …