Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that can change the
expression of downstream target genes by catalyzing the trimethylation of lysine 27 of …

Not only genetic but also epigenetic factors are closely associated with cancer, especially
with its malignant evolution. Cancer therapies based on epigenetic modulation have …

药物治疗是急性髓细胞性白血病 (AML) 的核心治疗策略, 但目前的治疗药物普遍存在生物利用
度低, 不良反应大, 静脉给药不便等缺陷. 纳米药物递送系统通过针对性优化药物的递送方式可以 …

Acute myeloid leukemia (AML), which is common in the elderly population, accounts for poor
long-term survival with a high possibility of relapse. The associated lack of currently …

Acute myeloid leukemia (AML), although genetically and morphologically distinct from other
B and T cell ALL subtypes, has one of the most rapidly progressing course and worse …

Glioblastoma (GBM) is a complex brain cancer with frequent relapses and high mortality and
still awaits effective treatment. Mitochondria dysfunction is a pathogenic condition in GBM …

Epigenetics mechanisms play a significant role in human diseases by altering DNA
methylation status, chromatin structure, and/or modifying histone proteins. By modulating the …

Parkinson's disease (PD) is the second most neurodegenerative disease caused due to
synucleinopathy leads to the death of dopaminergic and serotonergic neurons. The …

Drug resistance presents a formidable challenge in the realm of breast cancer therapy.
Accumulating evidence suggests that enhancer of zeste homolog 2 (EZH2), a component of …

In recent years, methylation modification has been determined to be vital for the biological
regulation of normal cells, tumor cells, and tumor microenvironment immune cells. Enhancer …