Epithelial sodium channels (ENaC) are part of a complex network of interacting biochemical
pathways and as such are involved in several disease states. Dependent on site and type of …

The (pro) renin receptor (PRR) is a multifunctional protein that is expressed in multiple
organs. Binding of prorenin/renin to the PRR activates angiotensin II–dependent and …

Cardiovascular diseases (CVDs), including all types of disorders related to the heart or
blood vessels, are the major public health problems and the leading causes of mortality …

The (pro) renin receptor (PRR) was originally cloned as a specific single-transmembrane
receptor for prorenin and renin and has now emerged as a multifunctional protein implicated …

The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular
diseases. In addition to the circulating RAS, local tissue RAS has been identified in various …

Abstract The (pro) renin receptor ((P) RR) is not only a member of the renin-angiotensin
system (RAS) but also exerts several RAS-independent functions due to its multiple signal …

Obesity increases the risk of renal damage, but the mechanisms are not clear. Normally,
kidneys autoregulate to keep the glomerular capillary pressure (PGC), renal blood flow, and …

Aberrant expression of serum-glucocorticoid kinase 1 (SGK1) contributes to the
pathogenesis of multiple disorders, including diabetes, hypertension, obesity, fibrosis, and …

Recent studies suggested that renal gluconeogenesis is substantially stimulated in the
kidney in presence of obesity. However, the mechanisms responsible for such stimulation …

We have previously shown that activation of (pro) renin receptor (PRR) induces epithelial
Na+ channel (ENaC) activity in cultured collecting duct cells. Here, we examined the role of …