Antimicrobial peptides: classification, design, application and research progress in multiple fields

Y Huan, Q Kong, H Mou, H Yi - Frontiers in microbiology, 2020 - frontiersin.org
Antimicrobial peptides (AMPs) are a class of small peptides that widely exist in nature and
they are an important part of the innate immune system of different organisms. AMPs have a …

The chemistry and biological activities of peptides from amphibian skin secretions

X Xu, R Lai - Chemical reviews, 2015 - ACS Publications
Amphibian skin is directly exposed to different environments. Amphibians interact with
environmental factors including microorganisms, parasites, predators, and physical factors …

In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design

WF Porto, L Irazazabal, ESF Alves, SM Ribeiro… - Nature …, 2018 - nature.com
Plants are extensively used in traditional medicine, and several plant antimicrobial peptides
have been described as potential alternatives to conventional antibiotics. However, after …

Antimicrobial peptides: amphibian host defense peptides

J Patocka, E Nepovimova, B Klimova… - Current medicinal …, 2019 - ingentaconnect.com
Antimicrobial Peptides (AMPs) are one of the most common components of the innate
immune system that protect multicellular organisms against microbial invasion. The vast …

[PDF][PDF] Antimicrobial peptides from frog skin: biodiversity and therapeutic promises

A Ladram, P Nicolas - Front. Biosci, 2016 - article.imrpress.com
More than a thousand antimicrobial peptides (AMPs) have been reported in the last decades
arising from the skin secretion of amphibian species. Generally, each frog species can …

Emerging therapeutic targets for treatment of leishmaniasis

S Sundar, B Singh - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Parasitic diseases that pose a threat to human life include leishmaniasis–
caused by protozoan parasite Leishmania species. Existing drugs have limitations due to …

[HTML][HTML] Selective amino acid substitution reduces cytotoxicity of the antimicrobial peptide mastoparan

LN Irazazabal, WF Porto, SM Ribeiro, S Casale… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The emergence of antibiotic-resistant clinical isolates and the decreased rate of
development of new antibiotics are a constant threat to human health. In this context, the …

Short peptides and their mimetics as potent antibacterial agents and antibiotic adjuvants

A Panjla, G Kaul, S Chopra, A Titz… - ACS Chemical …, 2021 - ACS Publications
Antimicrobial resistance (AMR) has been increasing unrelentingly worldwide, thus
negatively impacting human health. The discovery and development of novel antibiotics is …

Therapeutic potential of antimicrobial peptides against pathogenic protozoa

CL Hagemann, AJ Macedo, T Tasca - Parasitology Research, 2024 - Springer
Protozoal infections cause significant morbidity and mortality in humans and animals. The
use of several antiprotozoal drugs is associated with serious adverse effects and resistance …

Temporins: an approach of potential pharmaceutic candidates

SM Romero, AB Cardillo, MC Martínez Ceron… - Surgical …, 2020 - liebertpub.com
Antimicrobial peptides (AMPs), also known as host defense peptides, are small and mostly
polycationic molecules that form part of the innate immune response. There are currently …