Cellular and molecular differences between HFpEF and HFrEF: a step ahead in an improved pathological understanding

SJ Simmonds, I Cuijpers, S Heymans, EAV Jones - Cells, 2020 - mdpi.com
Heart failure (HF) is the most rapidly growing cardiovascular health burden worldwide. HF
can be classified into three groups based on the percentage of the ejection fraction (EF) …

Endothelial dysfunction and vascular disease–a 30th anniversary update

PM Vanhoutte, H Shimokawa, M Feletou… - Acta …, 2017 - Wiley Online Library
The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Lean mass abnormalities in heart failure: the role of sarcopenia, sarcopenic obesity, and cachexia

S Carbone, HE Billingsley… - Current problems in …, 2020 - Elsevier
The role of body composition in patients with heart failure (HF) has been receiving much
attention in the last few years. Particularly, reduced lean mass (LM), the best surrogate for …

Lipoic acid: its antioxidant and anti-inflammatory role and clinical applications

F Andrea Moura, K Queiroz de Andrade… - Current Topics in …, 2015 - ingentaconnect.com
Lipoic acid (LA) is an antioxidant able to produce its effects in aqueous or lipophilic
environments. Lipoate is the conjugate base of lipoic acid, and the most prevalent form of LA …

Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization

DM Hirai, TI Musch, DC Poole - American Journal of …, 2015 - journals.physiology.org
Chronic heart failure (CHF) impairs critical structural and functional components of the O2
transport pathway resulting in exercise intolerance and, consequently, reduced quality of …

Concurrent diabetes and heart failure: interplay and novel therapeutic approaches

QG Karwi, KL Ho, S Pherwani, EB Ketema… - Cardiovascular …, 2022 - academic.oup.com
Diabetes mellitus increases the risk of developing heart failure, and the co-existence of both
diseases worsens cardiovascular outcomes, hospitalization, and the progression of heart …

CORP: Ultrasound assessment of vascular function with the passive leg movement technique

JR Gifford, RS Richardson - Journal of applied physiology, 2017 - journals.physiology.org
As dysfunction of the vascular system is an early, modifiable step in the progression of many
cardiovascular diseases, there is demand for methods to monitor the health of the vascular …

Evidence of microvascular dysfunction in heart failure with preserved ejection fraction

JF Lee, Z Barrett-O'Keefe, RS Garten, AD Nelson… - Heart, 2016 - heart.bmj.com
Objective While vascular dysfunction is well defined in patients with heart failure (HF) with
reduced ejection fraction (HFrEF), disease-related alterations in the peripheral vasculature …

Vascular dysfunction and chronic obstructive pulmonary disease: the role of redox balance

SJ Ives, RA Harris, MAH Witman, AS Fjeldstad… - …, 2014 - Am Heart Assoc
Chronic obstructive pulmonary disease (COPD) is characterized by low pulmonary function,
inflammation, free radical production, vascular dysfunction, and subsequently a greater …

Further peripheral vascular dysfunction in heart failure patients with a continuous-flow left ventricular assist device: the role of pulsatility

MAH Witman, RS Garten, JR Gifford, HJ Groot… - JACC: Heart Failure, 2015 - jacc.org
Objectives: Using flow-mediated vasodilation (FMD) and reactive hyperemia (RH), this study
aimed to provide greater insight into left ventricular assist device (LVAD)–induced changes …