The liver partakes as a sensor and effector of peripheral metabolic changes and a regulator
of systemic blood and nutrient circulation. As such, abnormalities arising from liver …

Bile acids (BAs) function as detergents promoting nutrient absorption and as hormones
regulating nutrient metabolism. Most BAs are key regulatory factors of physiological …

Maternal obesity programs the risk for development of nonalcoholic fatty liver disease
(NAFLD) in offspring. Maternal exercise is a potential intervention to prevent …

The unfolded protein response (UPR) is a complex adaptive signaling pathway activated by
the accumulation of misfolded proteins in the endoplasmic reticulum (ER). ER stress (ERS) …

Irritable bowel syndrome (IBS) is a chronic disorder, which its causative agent is not
completely clear; however, the interaction between microorganisms and gastrointestinal (GI) …

The mechanisms by which maternal obesity increases the susceptibility to steatotic liver
disease in offspring are incompletely understood. Models using different maternal …

Obesity is a medical condition described as excess body weight in the form of fat. Although
the first recorded use of the word “obesity” was by Randle Cotgrave in 1611 (1), obesity (in …

Human and animal model data show that maternal obesity promotes nonalcoholic fatty liver
disease in offspring and alters bile acid (BA) homeostasis. Here we investigated whether …

Prenatal dexamethasone exposure (PDE) can lead to increased susceptibility to various
diseases in adult offspring, but its effect on gut microbiota composition and the relationship …

Background: The unfolded protein response (UPR) is a complex adaptive signaling pathway
39 activated by accumulation of misfolded proteins in the endoplasmic reticulum (ER). ER …