The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

The functional properties of molecular systems are generally determined by the sum of many
weak non-covalent interactions, and therefore methods for predicting the relative …

Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Highlights•Multi-drug co-crystals would offer an efficient solution to combat various
diseases.•Cocrystals would play vital role in market due to expanded patent …

Chiral separation has already become a crucial topic for effectively utilizing superfluous
racemates synthesized by chemical means and satisfying the growing requirements for …

Design and synthesis of pharmaceutical cocrystals have received great interest in recent
years. Cocrystallization of drug substances offers a tremendous opportunity for the …

Cocrystals are crystalline single phase materials composed of two or more different
molecular and/or ionic compounds generally in a stoichiometric ratio which are neither …

A machine-learning model trained on the whole Cambridge Structural Database was
developed to assist high-throughput cocrystal screening. With only 2D structures taken as …

In this study, the existing set of carbamazepine (CBZ) cocrystals was extended through the
successful combination of the drug with the positional isomers of acetamidobenzoic acid …