Next generation probiotics: Engineering live biotherapeutics
SK Murali, TJ Mansell - Biotechnology Advances, 2024 - Elsevier
The population dynamics of the human microbiome have been associated with inflammatory
bowel disease, cancer, obesity, autoimmune diseases, and many other human disease …
bowel disease, cancer, obesity, autoimmune diseases, and many other human disease …
Advances in ligand-specific biosensing for structurally similar molecules
The specificity of biological systems makes it possible to develop biosensors targeting
specific metabolites, toxins, and pollutants in complex medical or environmental samples …
specific metabolites, toxins, and pollutants in complex medical or environmental samples …
Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach
The probiotic yeast Saccharomyces boulardii (Sb) is a promising chassis to deliver
therapeutic proteins to the gut due to Sb's innate therapeutic properties, resistance to phage …
therapeutic proteins to the gut due to Sb's innate therapeutic properties, resistance to phage …
Programming Probiotics: Diet-Responsive Gene Expression and Colonization Control in Engineered S. boulardii
D Durmusoglu, DJ Haller, IS Al'Abri, K Day… - ACS Synthetic …, 2024 - ACS Publications
Saccharomyces boulardii (Sb) is an emerging probiotic chassis for delivering biomolecules
to the mammalian gut, offering unique advantages as the only eukaryotic probiotic …
to the mammalian gut, offering unique advantages as the only eukaryotic probiotic …
High‐throughput G protein‐coupled receptor‐based autocrine screening for secondary metabolite production in yeast
TE Saleski, H Peng, B Lengger, J Wang… - Biotechnology and …, 2024 - Wiley Online Library
Biosensors are valuable tools in accelerating the test phase of the design‐build‐test‐learn
cycle of cell factory development, as well as in bioprocess monitoring and control. G protein …
cycle of cell factory development, as well as in bioprocess monitoring and control. G protein …
Harnessing chemical space neural networks to systematically annotate GPCR ligands
FG Hansson, NG Madsen, LG Hansen, T Jakociunas… - BioRxiv, 2024 - biorxiv.org
Drug-target interaction databases comprise millions of manually curated data points, yet
there are missed opportunities for repurposing established interaction networks to infer …
there are missed opportunities for repurposing established interaction networks to infer …
Engineered yeast cells simulating CD19+ cancers to control CAR T cell activation
M Deichmann, G Schiesaro, K Ramanathan… - BioRxiv, 2023 - biorxiv.org
Chimeric antigen receptor (CAR) T cells have become an established form of
immunotherapy and continue to show promising results for the treatment of hematological …
immunotherapy and continue to show promising results for the treatment of hematological …
Biosensor-Assisted Laboratory Evolution of Malonyl-CoA production in Saccharomyces cerevisiae
The production of bio-based chemicals and fuels through microbial engineering offers a
promising and sustainable alternative to petroleum-based fuels and chemicals, with the …
promising and sustainable alternative to petroleum-based fuels and chemicals, with the …
Engineered yeast cells simulating CD19+ cancers to control CAR T cell activation
Chimeric antigen receptor (CAR) T cells have become an established immunotherapy and
show promising results for the treatment of hematological cancers in most patients …
show promising results for the treatment of hematological cancers in most patients …
[图书][B] Establishing Probiotic Yeast Saccharomyces boulardii as an In-Gut Biomanufacturing Platform
D Durmusoglu - 2022 - search.proquest.com
Engineered probiotics are genetically modified microorganisms to perform sophisticated
diagnostic, preventative and/or therapeutic functions in the gut. Up to date, majority of this …
diagnostic, preventative and/or therapeutic functions in the gut. Up to date, majority of this …