Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

Objective Central sensitization (CS), a mechanism explaining the persistence of symptoms,
has been the focus of many research projects. Explanations given to patients with chronic …

A large number of pharmacological studies have used capsaicin as a tool to activate many
physiological systems, with an emphasis on pain research but also including functions such …

Quantification of the human painful sensory experience is an essential step in the translation
of knowledge from animal nociception to human pain. Translational models for assessment …

Irritable bowel syndrome (IBS) remains a clinical challenge in the 21 st century. It's the most
commonly diagnosed gastrointestinal condition and also the most common reason for …

Background Intravenous infusion of lidocaine decreases postoperative pain and speeds the
return of bowel function. The authors therefore tested the hypothesis that perioperative …

Recent insights have demonstrated a central role for dopaminergic neurotransmission in
modulating pain perception and natural analgesia within supraspinal regions, including the …

AS part of the effort to develop mechanisms-based approaches to pain therapy, renewed
interest has focused on the use of ketamine for treatment of acute and chronic pain. In …

Patients with gastro-oesophageal reflux disease (GORD) who are not responding to proton
pump inhibitors (PPIs) given once daily are very common. Various underlying mechanisms …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …