The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …

The proper restraint of the destructive potential of the immune system is essential for
maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their …

During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism
against pathogens. However, the cellular self-protective mechanism against such potential …

Summary YAP and TAZ (YAP/TAZ), two major effectors of the Hippo signaling pathway, are
frequently activated in human cancers. The activity of YAP/TAZ is strictly repressed upon …

Proper cellular functionality and homeostasis are maintained by the convergent integration
of various signaling cascades, which enable cells to respond to internal and external …

Mitochondria need to be juxtaposed to phagosomes for the synergistic production of ample
reactive oxygen species (ROS) in phagocytes to kill pathogens. However, how phagosomes …

An imbalance in the lineages of immunosuppressive regulatory T cells (Treg cells) and the
inflammatory TH17 subset of helper T cells leads to the development of autoimmune and/or …

Since its discovery, the Hippo pathway has emerged as a central signaling network in
mammalian cells. Canonical signaling through the Hippo pathway core components …

Forkhead box O (FOXO) transcription factors are central regulators of cellular homeostasis.
FOXOs respond to a wide range of external stimuli, including growth factor signaling …