Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges

CY Loh, JY Chai, TF Tang, WF Wong, G Sethi… - Cells, 2019 - mdpi.com
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

[HTML][HTML] Luteolin, a flavonoid, as an anticancer agent: A review

M Imran, A Rauf, T Abu-Izneid, M Nadeem… - Biomedicine & …, 2019 - Elsevier
Many food-derived phytochemicals and their derivatives represent a cornucopia of new anti-
cancer compounds. Luteolin (3, 4, 5, 7-tetrahydroxy flavone) is a flavonoid found in different …

From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders

MS Hussain, G Gupta, A Goyal, R Thapa… - … of biochemical and …, 2023 - Wiley Online Library
Inflammation is an essential immune response that helps fight infections and heal tissues.
However, chronic inflammation has been linked to several diseases, including cancer …

Therapeutic potential of luteolin on cancer

M Çetinkaya, Y Baran - Vaccines, 2023 - mdpi.com
Cancer is a global concern, as the rate of incidence is increasing each year. The challenges
related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to …

Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis

YL Feng, DQ Chen, ND Vaziri, Y Guo… - Medicinal research …, 2020 - Wiley Online Library
Tissue fibrosis and cancer both lead to high morbidity and mortality worldwide; thus,
effective therapeutic strategies are urgently needed. Because drug resistance has been …

[HTML][HTML] NF-κB inhibitors gifted by nature: The anticancer promise of polyphenol compounds

C Guan, X Zhou, H Li, X Ma, J Zhuang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Polyphenol compounds are natural antioxidants, which are rich in anti-inflammatory and
antioxidant components. They have a wide range of medicinal benefits that are believed to …

Molecular targets of luteolin in cancer

MJ Tuorkey - European Journal of Cancer Prevention, 2016 - journals.lww.com
Many food-derived phytochemical compounds and their derivatives represent a cornucopia
of new anticancer compounds. Despite extensive study of luteolin, the literature has no …

Multi-faceted role of luteolin in cancer metastasis: EMT, angiogenesis, ECM degradation and apoptosis

MT Rocchetti, F Bellanti, M Zadorozhna… - International Journal of …, 2023 - mdpi.com
Luteolin (3′, 4′, 5, 7-tetrahydroxyflavone), a member of the flavonoid family derived from
plants and fruits, shows a wide range of biomedical applications. In fact, due to its anti …

Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy

C Rajagopal, MB Lankadasari, JM Aranjani… - Pharmacological …, 2018 - Elsevier
Inflammation is one of the major causative factor of cancer and chronic inflammation is
involved in all the major steps of cancer initiation, progression metastasis and drug …