[HTML][HTML] Chronic pain: structural and functional changes in brain structures and associated negative affective states

S Yang, MC Chang - International journal of molecular sciences, 2019 - mdpi.com
Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …

Etiology and pharmacology of neuropathic pain

SRA Alles, PA Smith - Pharmacological reviews, 2018 - ASPET
Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

[HTML][HTML] Dorsal root ganglion infiltration by macrophages contributes to paclitaxel chemotherapy-induced peripheral neuropathy

H Zhang, Y Li, M de Carvalho-Barbosa, A Kavelaars… - The journal of pain, 2016 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) is a disruptive and persistent side
effect of cancer treatment with paclitaxel. Recent reports showed that paclitaxel treatment …

[HTML][HTML] Chemotherapy-induced peripheral neuropathy: part 1—current state of knowledge and perspectives for pharmacotherapy

K Sałat - Pharmacological reports, 2020 - Springer
Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …

Pain pathways and nervous system plasticity: learning and memory in pain

B McCarberg, J Peppin - Pain Medicine, 2019 - academic.oup.com
Objective This article reviews the structural and functional changes in pain chronification
and explores the association between memory and the development of chronic pain …

[HTML][HTML] A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced …

ME Lynch, P Cesar-Rittenberg, AG Hohmann - Journal of pain and …, 2014 - Elsevier
Context Neuropathic pain caused by chemotherapy limits dosing and duration of potentially
life-saving anti-cancer treatment and impairs quality of life. Chemotherapeutic neuropathy …

[HTML][HTML] Toll-like receptor 4 signaling contributes to Paclitaxel-induced peripheral neuropathy

Y Li, H Zhang, H Zhang, AK Kosturakis, AB Jawad… - The Journal of …, 2014 - Elsevier
This paper tests the contribution of the toll-like receptors, TLR4 in particular, in the initiation
and maintenance of paclitaxel-related chemotherapy-induced peripheral neuropathy. TLR4 …

Taxane‐induced neurotoxicity: Pathophysiology and therapeutic perspectives

R da Costa, GF Passos, NLM Quintão… - British journal of …, 2020 - Wiley Online Library
Taxane‐derived drugs are antineoplastic agents used for the treatment of highly common
malignancies. Paclitaxel and docetaxel are the most commonly used taxanes; however …

Mechanisms involved in the development of chemotherapy-induced neuropathy

JA Boyette-Davis, ET Walters, PM Dougherty - Pain management, 2015 - Future Medicine
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and painful condition
seen in patients undergoing treatment with common agents such as vincristine, paclitaxel …

Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and …

CM Peters, JM Jimenez-Andrade, BM Jonas… - Experimental …, 2007 - Elsevier
Paclitaxel-induced peripheral neuropathy (PN) can be a significant problem for patients
receiving chemotherapeutic regimens for the treatment of breast, ovarian, and lung cancer …