Within the sperm nucleus the paternal genome remains functionally inert and protected
following protamination. This is marked by a structural morphogenesis that is heralded by a …

BACKGROUND The subject of epigenetic risk of assisted reproduction treatment (ART),
initiated by reports on an increase of children with the Beckwith–Wiedemann imprinting …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …

In higher eukaryotes, histone methylation is involved in maintaining cellular identity during
somatic development. As most nucleosomes are replaced by protamines during …

This article reports the results of the most recent in a series of EHSRE workshops designed
to synthesize the current state of the field in Andrology and provide recommendations for …

The different configurations of maternal and paternal chromatin, acquired during oogenesis
and spermatogenesis, have to be rearranged after fertilization to form a functional embryonic …

The segregation of eukaryotic genomes into euchromatin and heterochromatin represents a
fundamental and poorly understood process. Here, we demonstrate that genome-wide …

STUDY QUESTION Can genome-wide haplotyping increase success following
preimplantation genetic testing for a monogenic disorder (PGT-M) by including zygotes with …

Early embryonic development is characterized by dramatic changes in cell potency and
chromatin organization. The role of histone variants in the context of chromatin remodeling …

Purpose We aimed to identify the correlation between morphological pronuclear (PN) status
and the genetically determined ploidy configuration in preimplantation embryos. Methods A …