Biomarkers are assayed to assess biological and pathological status. Recent advances in
high-throughput proteomic technology provide opportunities for developing next generation …

The ability to conduct validated analyses of biomarkers is critically important in order to
establish the sensitivity and selectivity of the biomarker in identifying a particular disease …

Bevacizumab, an antibody against vascular endothelial growth factor (VEGF), is a
promising, yet controversial, drug in human glioblastoma treatment (GBM). Its effects on …

Background Nowadays, researchers are leveraging the mRNA-based vaccine technology
used to develop personalized immunotherapy for cancer. However, its application against …

The cytochrome-b 5 reductase (CYB5R) family of flavoproteins is known to regulate
reduction-oxidation (redox) balance in cells. The five enzyme members are highly …

Background Lower-grade glioma (LGG) is a highly heterogeneous disease that presents
challenges in accurately predicting patient prognosis. Mitochondria play a central role in the …

Plasma membrane proteins that are exposed on the cell surface have important biological
functions, such as signaling into and out of the cells, ion transport, and cell-cell and cell …

Validated biomarkers for patients suffering from gliomas are urgently needed for
standardizing measurements of the effects of treatment in daily clinical practice and trials …

Abstract Annexin A5 (Anxa5) promotes pancreatic adenocarcinoma, sarcoma,
tumorigenesis and progression of breast cancer and prostate cancer stem cells. It is involved …

Glioblastoma, a grade IV astrocytoma, is regarded as the most aggressive primary brain
tumour with an overall median survival of 16.0 months following the standard treatment …