Diagnosis and treatment of NMO spectrum disorder and MOG-encephalomyelitis

N Borisow, M Mori, S Kuwabara, M Scheel… - Frontiers in …, 2018 - frontiersin.org
Neuromyelitis optica spectrum disorders (NMOSD) are autoantibody mediated chronic
inflammatory diseases. Serum antibodies (Abs) against the aquaporin-4 water channel lead …

Transcranial magnetic stimulation as a potential biomarker in multiple sclerosis: a systematic review with recommendations for future research

NJ Snow, KP Wadden, AR Chaves… - Neural …, 2019 - Wiley Online Library
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system. Disease
progression is variable and unpredictable, warranting the development of biomarkers of …

Assessments of vessel density and foveal avascular zone metrics in multiple sclerosis: an optical coherence tomography angiography study

H Yilmaz, A Ersoy, E Icel - Eye, 2020 - nature.com
Abstract Background/Objectives To investigate optical coherence tomography angiography
(OCT-A) findings of foveal avascular zone (FAZ) metrics and macular & peripapillary vessel …

Suggestions for improving the design of clinical trials in multiple sclerosis—results of a systematic analysis of completed phase III trials

S Gehr, T Kaiser, R Kreutz, WD Ludwig, F Paul - EPMA Journal, 2019 - Springer
This manuscript reviews the primary and secondary endpoints of pivotal phase III trials with
immunomodulatory drugs in multiple sclerosis (MS). Considering the limitations of previous …

Visualizing the central nervous system: imaging tools for multiple sclerosis and neuromyelitis optica spectrum disorders

J Kuchling, F Paul - Frontiers in Neurology, 2020 - frontiersin.org
Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are
autoimmune central nervous system conditions with increasing incidence and prevalence …

Ozanimod for the treatment of relapsing remitting multiple sclerosis

L Rasche, F Paul - Expert Opinion on Pharmacotherapy, 2018 - Taylor & Francis
Introduction Ozanimod is a selective sphingosine 1-phosphate receptor 1 and 5 modulator
under development by Celgene, for the treatment of relapsing remitting multiple sclerosis …

Optic chiasm measurements may be useful markers of anterior optic pathway degeneration in neuromyelitis optica spectrum disorders

V Juenger, G Cooper, C Chien, M Chikermane… - European …, 2020 - Springer
Objectives We aimed to evaluate optic chiasm (OC) measures as potential imaging marker
for anterior optic pathway damage assessment in the context of neuromyelitis optica …

The immediate effect of stroboscopic visual training on information-processing time in people with multiple sclerosis: an exploratory study

N Shalmoni, A Kalron - Journal of Neural Transmission, 2020 - Springer
Stroboscopic visual training (SVT) is a form of training aimed at improving visual and
perceptual performance by having individuals perform activities under conditions of …

Imaging correlates of visual function in multiple sclerosis

E Caverzasi, C Cordano, AH Zhu, C Zhao, A Bischof… - PloS one, 2020 - journals.plos.org
No single neuroimaging technique or sequence is capable of reflecting the functional
deficits manifest in MS. Given the interest in imaging biomarkers for short-to medium-term …

Fingolimod after a first unilateral episode of acute optic neuritis (MOVING)–preliminary results from a randomized, rater-blind, active-controlled, phase 2 trial

C Albert, J Mikolajczak, A Liekfeld, SK Piper, M Scheel… - BMC neurology, 2020 - Springer
Background Neuroprotection and promotion of remyelination represent important
therapeutic gaps in multiple sclerosis (MS). Acute optic neuritis (ON) is a frequent MS …