Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

It has been one and a half centuries since Enrico Sertoli published the seminal discovery of
the testicular 'nurse cell', not only a key cell in the testis, but indeed one of the most amazing …

This review addresses current understanding of the germline stem cell niche unit in
mammalian testes. Spermatogenesis is a classic model of tissue-specific stem cell function …

Germ cell development creates totipotency through genetic as well as epigenetic regulation
of the genome function. Primordial germ cells (PGCs) are the first germ cell population …

Spermatogenesis is a continuous and productive process supported by the self-renewal and
differentiation of spermatogonial stem cells (SSCs), which arise from undifferentiated …

Male infertility is a multifactorial complex disease with highly heterogeneous phenotypic
representation and in at least 15% of cases, this condition is related to known genetic …

The regulated migration of cells is essential for development and tissue homeostasis, and
aberrant cell migration can lead to an impaired immune response and the progression of …

Stem cells are rare cells that are uniquely capable of both reproducing themselves (self-
renewing) and generating the differentiated cell types that are needed to carry out …

Malignant cells from at least 23 different types of cancer express the chemokine receptor
CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved …

In bone marrow, hematopoiesis is thought to depend on special microenvironments known
as niches that maintain blood cells. However, the identity of niches and interaction of blood …