BACKGROUND A frequent complication of anticancer treatment, oral and gastrointestinal
(GI) mucositis, threatens the effectiveness of therapy because it leads to dose reductions …

Abstract Learning Objectives After completing this course, the reader will be able to: Identify
trials that have demonstrated a survival benefit with a modern chemotherapeutic agent or …

Purpose This phase III study compared the efficacy and safety of bevacizumab (BV) when
combined with several standard chemotherapy regimens versus those regimens alone for …

Over the last decade, clinicians have accepted that while survival and disease-free survival
are critical factors for cancer patients, overall quality-of-life is fundamental. This review …

Genexol-PM is a novel Cremophor EL-free polymeric micelle formulation of paclitaxel. This
single arm, multicenter phase II study was designed to evaluate the efficacy and safety of …

BACKGROUND The objective of this study was to compare the efficacy and toxicity of the
liposome‐encapsulated doxorubicin, TLC D‐99 (Myocet, Elan Pharmaceuticals, Princeton …

Paclitaxel is an anticancer agent efficacious in the treatment of ovarian, breast, and lung
cancer. Due to a strong link between the pharmacokinetics and therapeutic efficacy of …

Purpose This randomized, controlled, multicenter, open-label, phase III study compared
docetaxel versus paclitaxel in patients with advanced breast cancer that had progressed …

Purpose The objective of this phase III global study was to compare the efficacy of
gemcitabine plus paclitaxel (GT) versus paclitaxel in patients with advanced breast cancer. It …

The acute cellular response to stress generates a subpopulation of reversibly stress-tolerant
cells under conditions that are lethal to the majority of the population. Stress tolerance is …