Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …

Cell-cell adhesions are critical for the development and maintenance of tissues. Present at
sites of cell-cell contact are the adherens junctions and tight junctions. The adherens …

Tight junctions are cell-adhesion complexes that seal tissues and are involved in cell
polarity and signaling. Supra-molecular assembly and positioning of tight junctions as …

Background Metastasis causes the majority of cancer-related deaths worldwide. Increasing
studies have revealed that circRNAs are associated with the carcinogenesis and metastasis …

Intercellular junctions are crucial for mechanotransduction, but whether tight junctions
contribute to the regulation of cell–cell tension and adherens junctions is unknown. Here, we …

The tight junction creates an intercellular barrier limiting paracellular movement of solutes
and material across epithelia. Currently many proteins have been identified as components …

The blood-retinal barrier (BRB) regulates transport across retinal capillaries maintaining
proper neural homeostasis and protecting the neural tissue from potential blood borne …

Epithelial and endothelial monolayers are multicellular sheets that form barriers between the
'outside'and 'inside'of tissues. Cell-cell junctions, made by adherens junctions, tight junctions …

Morphogenesis requires dynamic coordination between cell–cell adhesion and the
cytoskeleton to allow cells to change shape and move without losing tissue integrity. We …

The intestinal epithelial apical junctional complex, which includes tight and adherens
junctions, contributes to the intestinal barrier function via their role in regulating paracellular …