The midcycle surge of LH sets in motion interconnected networks of signaling cascades to
bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators …

BACKGROUND Initially identified for their capability to induce heterotopic bone formation,
bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the …

Understanding the physiology underlying the complex dialog between the oocyte and its
surrounding somatic cells within the ovarian follicle has been crucial in defining optimal …

Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive
fibrosis, ultimately leading to end‐stage renal disease. Although many studies have …

Epiregulin is a 46-amino acid protein that belongs to the epidermal growth factor (EGF)
family of peptide hormones. Epiregulin binds to the EGF receptor (EGFR/ErbB1) and ErbB4 …

Expression of cyclooxygenase 2 (COX2, now known as PTGS2), prostaglandin E2 synthase
(PTGES, PGES), and prostaglandin F2α synthase (PGFS), of the respective receptors …

Prostaglandins are well known to be central regulators of vertebrate ovulation. Studies
addressing the role of prostaglandins in mammalian ovulation have established that they …

Pyruvate kinase M2 (PKM2) is a key enzyme of glycolysis, which is highly expressed in
many tumor cells, and has emerged as an important player in tumor progression and …

Prostaglandins (PGs) are important lipid mediators produced from arachidonic acid via the
sequential catalyzation of cyclooxygenases (COXs) and specific prostaglandin synthases …

Context: Regulation of progesterone production in granulosa cells is important for normal
reproductive functions. Steroidogenic acute regulatory protein (StAR) is recognized as the …