Monkeypox virus (MPXV), which causes disease in humans, has for many years been
restricted to the African continent, with only a handful of sporadic cases in other parts of the …

Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with
potential to provide greater clinical benefit to patients with advanced-stage cancer. In …

Oncolytic viruses have the potential to induce immunogenic cell death (ICD) that may
provoke potent and long-lasting anti-cancer immunity. Here we aimed to characterize the …

Viruses are ubiquitous intracellular genetic parasites that heavily rely on the infected cell to
complete their replication life cycle. This dependency on the host machinery forces viruses …

Oncolytic immunotherapy is a promising novel therapeutic for cancer, and further preclinical
studies may maximize its therapeutic efficacy. In this study, we construct a novel oncolytic …

Abstract Currently, 33 gene‐therapy drugs/products have been approved in the clinic. Over
3000 completed and ongoing clinical gene therapy trials have been reported worldwide …

Oncolytic virotherapy has emerged as a promising treatment for human cancers owing to an
ability to elicit curative effects via systemic administration. Tumor cells often create an …

Although one member of the poxvirus family, variola virus, has caused one of the most
devastating human infections worldwide, smallpox, the knowledge gained over the last 30 …

Apoptosis is a form of cellular suicide initiated either via extracellular (extrinsic apoptosis) or
intracellular (intrinsic apoptosis) cues. This form of programmed cell death plays a crucial …

Enterovirus 71 (EV71) is a dominant pathogenic agent that may cause severe central
nervous system (CNS) diseases among infants and young children in the Asia-pacific. The …