Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during
embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds …

WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Summary The Hippo transducers YAP/TAZ have been shown to play positive, as well as
negative, roles in Wnt signaling, but the underlying mechanisms remain unclear. Here, we …

Cell surface transmembrane receptors often form nanometer-to micrometer-scale clusters to
initiate signal transduction in response to environmental cues. Extracellular ligand …

Background Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The
monoclonal antibody romosozumab binds to sclerostin and increases bone formation …

Although hormonal regulation of ovarian follicle development has been extensively
investigated, most studies concentrate on the development of early antral follicles to the …