Poor nations are already facing the heat of double burden of communicable and non-
communicable diseases (NCDs), often known as chronic illnesses, which are characterized …

SCD in India is not uniformly mild despite high fetal hemoglobin levels. The benefits of
comprehensive care and hydroxyurea therapy have been demonstrated. Newborn …

The single base molecular substitution characterizing sickle cell haemoglobin, β 6 glu→ val,
might be expected to result in predictable haematological and clinical features. However, the …

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hUapVK5dvms8 on 12/05/2023 specific symptoms. These features were similar to the mild …

Objectives To explore clinical, hematological and molecular features of homozygous sickle
cell (SS) disease in central India. Methods Focusing on the pediatric age group attending a …

clinical severity and the correlation between genotype and phenotype is poor10. Some of
the phenotypic heterogeneity can be explained by the different sickle haplotypes as …

The clinical diversity of SCD is described. The natural history of SCD in India is unfolding
from newborn screening programme. The use of low-dose hydroxy urea therapy both in …

Introduction: sickle cell disease is the most common inherited hemoglobin disease globally
and remains a significant concern worldwide and in Africa. This study aimed to determine …

India accounts for 14.5 percent of the global SCD newborns, roughly over 42,000 a year,
second to sub-Saharan Africa. Despite the availability of cheap diagnostic and treatment …

The severity of sickle cell disease (SCD) is frightening as 50-90 per cent of children do not
live to celebrate their 5 th birthday in Africa and India, while millions continue to suffer life …